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Hi everyone I’m Dr. Sanjeev Goel, and you’re listening to the Advanced Anti-aging and Technology Summit. And today my guest is Dr. Marcos de Andrade. Dr. de Andrade is a research physician and public speaker with a passion for preventative medicine located in Miami, Florida. He’s currently the Chief Executive Officer of US Medical Seminars, a research in the Preventative Medicine Company. Dr. de Andrade completed an undergraduate studies in biology at the Florida Atlantic University in Boca Raton, Florida. Shortly thereafter, D, Dr. de Andrade obtained his Doctor of Medicine Degree in a medical program between the United States and Europe at the University of Silesia in Katowice Poland.Â
He also possessed a Master of Business Administration Finance and Master International Business Administration from a Nova Southeastern University in Fort Lauderdale. Dr. de Andrade later went on to complete a postdoctoral research here at the Cleveland Clinic, Florida with a concentration in metabolism, general surgery and orthopedics. Dr. de Andrade has special interest in environmental preventative medicine. His passion lies in research, increasing community awareness of practices of healthy and lifespan successful living. Your gonna, I’m sure you’re going to enjoy today’s talk with him period. He’s sitting in Miami today at his clinic. Hi everyone. I’m Dr. Sanjeev Boyle and your listening to the Advanced Anti-aging and Technology Summit. And today I have Dr. de Andrade with me. How are you, Marcus?
Great, great. How about yourself?
Good, thank you for taking the time today. I really appreciate it. So you’re in warm Miami.
Oh yes. Can’t complain.
It’s the place where all my parents, my patients are going these days.
I don’t blame them.
So maybe before we get started if you could tell our listeners and viewers a little bit about how did you get into this whole field of longevity science? You know, I know your background’s MD and then you did an MBA. So you just kind of take us through that journey. That would be great.
Sure. Yeah. I mean the, the real root cause of how I became interested in this is actually, finished medical school at about 30 went to Cleveland clinic to do a post of research fellow in metabolism and in the surgery department. And I actually didn’t feel too well. I felt myself deteriorating, feeling extremely tired, feeling off. And I started actually getting some strange diagnoses from even colleagues of mine. And I ended up seeing that I didn’t really have the, either the, you know, some of the things they were telling me such as like depression and so forth.Â
I actually had burnout. I had adrenal fatigue, pretty bad which I know is not a recognized yet by traditional medicine. And I was at the same time, it was falling a little bit out of love for traditional medicine. So I had to dig deep into biology and immunology to actually figure myself out. I traveled a bit around the world, South America a lot. And I was able to, with the help of other doctors to bring myself back online and I tell everybody today I’m a comeback story. I feel great. And it brought me into the world of performance and longevity, which is where I wanna it’s the work I want to do for the rest of my days.
Yeah. That sounds very rewarding. You look like you’re definitely going to be living what you preach.
Oh yeah, yeah, yeah. I’m 73 years old.
Living here in the prime of your life, but so maybe just take us through, how do you, how do you look at at the whole aging process and, and, and the way you kind of, what’s your framework for when a patient comes in? I’d love to hear that.
Yeah, so first of all, I mean, working on this with this kind of this side of medicine one thing you have to do is educate real well your patients or clients as they’re coming in where they’re looking for, perhaps alternatives, you know maybe not so many alternatives based on pharmaceuticals et cetera, where they can feel better and in the immediate look better, right? That’d be the bigger, better, faster, stronger but also keep that for a long-term right? Because there are things that’ll help with the performance side of things but will also mess up the, on the longevity side.Â
So one thing I, I like to tell all our clients as soon as like the first few minutes of conversation and I find this a really good icebreaker, I tell them, look there’s 12,000 documented diseases and let that hold for a second. There’s 129 documented diseases. And you know, these are rough numbers since I’ve looked up these things, but you can trace back the, to the, the the etiology of all these diseases to four pillars which is sublimation, oxidation, glycation and inflammation. Okay. And then there, this is like a bird’s-eye view to explain the the pathophysiology behind a lot of disease. And because we’re either living in a constructive state or destructive state cause lots of clients say that when I’m not sick I’m coming in here just to do some, you know anti-aging and I tell them exactly what your body, right?Â
You have the parasympathetic and the sympathetic, body doesn’t have too many gears. It’s either like forward or reverse, right? So say we’re either constructing ourselves or these destructing ourselves, which one are you in? Right. And, and that’s a question I think we should be asking ourselves all the time. So if we’re not constructing disease if we’re not down the road of pathogenesis well then most likely, I mean, by default, we’re on the other side, we’re actually building ourselves up. We’re increasing our, our, our ability to live longer our ability to produce more in the short term and also live longer and healthier, not live long in a bed, right. The goal is to die as late, as young as possible, right. So that’s what I tell a lot of our clients. So, so yeah, the not to develop too much, I usually start off the conversation on those deep rooted beliefs that I personally have. And I think if you really look into the biochemistry and the immunology of things it make sense.
Okay. Let’s maybe take us through each one of these. So you’re saying the methylation piece, how, how does that figure into the being one of the four pillars?
So, for example, methylation, right? Gene regulation, cellular detoxification, right? So where that, those, I mean, those those processes are essential, right? Where genes are being regulated and you’re detoxifying cells. I tell clients all the time, like if we speak next year in this same outfit, our outfits are the same but our skin, hair, nails, everything is different, right? So we’re constantly re we’re in a process of renewal and then methylation, especially with the, you know this whole conversation on with the MTHFR gene, et cetera. There’s, it’s a huge topic to look at.Â
Not only from a genetic point of view but from a deficiency point of view where people don’t have their micronutrients, simple things like B vitamins and so forth, where the the cycles of methylation, the methylation cycle isn’t being properly carried out. And then that has an impact on the person again short-term and long-term, right. So yeah, the methylation is one of the first ones that I start off and I and I’ve seen us adjust a few people on that side and even get, you know, results in weight loss which we weren’t even trying to on, on that end, you know which so it’s methylation is just so all encompassing, one of the all encompassing pillars.
So you’re happy now, just as a workup do you do use genetic testing to look at the methylation pathway? Are you doing, what are you doing? Like look at their vitamin B status or I’m not too sure.
Yeah, yeah. So we’ll look at the the MTHFR components look to see if they’re homozygous or heterozygous or any of that. And then also look at the micronutrients and compare and contrast it. Usually everybody comes in with not the MTHFR but micronutrients it’s given our agricultural revolutions. Right. And the, our, the lack of our foods having micronutrients and as they did before the 1970s, et cetera. Yeah. Most of the time there’s something to fix there.
Right. Okay. And then the second one you mentioned was oxidation, right, if you want, do you want to talk a little bit about that? How does that fit into the plan?
Right, right. So we, we provide a lot of our clients with deep testing to see if there’s things such as heavy metals, chemical burden, et cetera, inside of them. And which, you know, when we do this it’s always really cool to see how impacted they are by seeing you know, oh my gosh, I have DPA’s or I have bisphenol or I have things like this inside of me that can actually cause issues in the longterm. So when we do the removal of these things and we, we’re proactive about helping the, the patient or the client to live cleaner, in that sense, you know all of a sudden you start to see better skin conditions you know, in, in, you know hair and just overall it’s, it’s an integrating part. That’s probably not the one, one of the pillars that you will see most impact. It’s really when you kind of put the whole thing together. But mainly what we’re looking for is for substances inside our clients that can lead to those, those problems.
And then glycation sounds, it’s it seems like it’s about sugar. Can you tell us?
Everybody knows insulin resistance. If you call it, I mean if we go call the devil by its name, you know it’s insulin resistance, we’re going to look for, you know, those things that are causing, you know, the, the big, I mean, an insulin is such a big conversation, right? Because it turns on mTOR, right? They talk about how cancers grow a lot with IGF one levels and growth hormone, et cetera. But I’m always like remind people a lot including our staff about what really is causing a lot of these cancers to grow is all, this are these high levels of insulin that don’t get taken care of, you know, and activate mTOR and so forth.Â
So yeah, that’s, that’s a very strong pillar. And now you could see that, you know with very basic blood work, it’s not something that would be like the other blood exams have to be a little bit more elaborated, let’s say, but but to help the client to control lication, it’s actually something, it, it’s not that hard, you know with food interventions, we, before we started recording we were talk about food. Yeah. For sure food comes into play. We map out our clients need, you know we do an exact gut sensitivities, leaky gut. We’re looking for all that. So that then we can apply proper strategy with food. I’m not, we can’t say, “Hey, let’s decrease all of this, you know, high-glycemic index food”. But then at the same time, we’re sending them down a bad immunological route where they’re, you know activating the leaky gut. And so, so it all kind of plays a whole role together. Right.
Just mentioned growth hormone and such. And you deal with a lot of athletes and such. I want to get your thoughts on, on people, you know using supplementing with with growth hormone.
So here our doctors, oh, sorry.
Yeah. We want to get thoughts on that, yeah.
Right, so here our doctors have not yet ever prescribed a growth hormone, even though it is something I’m very fond of. And we’re starting to contemplate that just because of all, you know when done in very physiologic doses, about two IUs per evening for, you know, I’m 190 pound male. That’s more than enough, you know? Oh, but what I really like and lately there’s been a little bit of controversial research, research, but IGF one, IGF one because of the, how it has 10% of the strength of insulin. So what it’ll do, it’ll help bring down also the, the growth hormone will raise sugar a little bit. So, eh, the IGF one has the same effect as the growth hormone in terms of the muscle, et cetera has one more physiologic effect, which is really good which is the cardiovascular system. The, their steady state seems to go up on athletes but also you give into a 60 year old diabetic with a bunch of comorbidities it proves very well with balancing levels of vitamin D and et cetera, balancing the other hormones. The IGF one at low dose works very well for just regular pathology.
So you’re saying, so you can give IGF one to, they don’t have the downstream effects of increased sugar or
The other way around it decreases sugar.
Right, right.
It decreases sugar. For example, myself, I run a very clean diet on myself. I just did kind of, I grew up in a blue zone. So I grew up seventh day Adventist. So we are one of the US blue zones. I never drank alcohol in my life, et cetera. So there are a few I really live by this. And so, because I run such low levels of sugar, I can’t use IGF for too long because I actually my sugar, I really feel my sugars coming, my sugar levels coming down. And so, yeah. And then what we’d like to do we have that resting calor, resting Calorimetry Device. So we see, like I consume a lot of carbs at rest, more than full fats.Â
So you give me the IGF one, this all has to be taken into in, into into play. But overall, I mean, there’s many studies showing that the growth hormone levels are very beneficial for people to live long, long-term and you know, something I like to always, I like to use logic a lot in your more youthful years where you have higher growth hormone levels is where you have less tumors proliferation of tumors, et cetera. It’s in your latter years where you don’t have your hormones, et cetera that you do have you develop these, you know these aberrations of, of the human body, right?Â
So it seems also that hormones and so forth they do can carry a protective effect for a lot of pathology, right. And the helping with Alzheimer’s, for example which is diabetes type three of the brain, right. Again, glycation issues, et cetera. So IGF one for us is it’s a very, very, it’s been I helped one of the pharmacies create the program for IGF one that we use. So I’m, I’m a big fan of IGF one.
Wow that’s interesting. Is there any downside at all, like, like constant stimulation of growth? Is there any concern indicative to breaks?
Yeah, so we’ll do 60, 90 days and we’ll do five days on two days off, you know, just to be cautious you know, do, like I said, I’m 190 pound male, I’m I think a 0.2mL’s per evening, you know five days a week is more than enough and it really helps to bring sugar levels down. Me personally, when I last time I did it, I, you know it was about HBA once he was about 5.2 it brought me quickly to a 4.7.
Oh wow.
Yeah. It works. I really like, and then, especially for when you’re it has a little bit of that effect of the testosterone on males, one in females too, where you mood, sleep. Oh my gosh, it’s a great regulator for sleep, you know? So there’s, for us it’s been very successful to use the IGF one.
Okay.
It’s a very nichey, not, everybody talks about growth hormone. And I always kind of raised the, like, I really like I really like, I like the growth hormone in IGF one silver but the IGF one was very interesting.
Yeah, no, that’s the first time I’ve heard that in so much detail. That’s really interesting. You were mentioning hormones. And what are your thoughts on, you know, how much supplementation needs to happen for testosterone, let say? Like, you know, 45, 50 year old when he’s–Â
Supplementation for how old?
Yeah. Like a 45, 50 year old men. What are you seeing with testosterone or what’s your thoughts about how often?
Especially when you’re balancing the whole system and if you’re properly balancing DHEA levels if you’re balancing, I’m talking about going down the whole pituitary axis, looking at the thyroid like here, we don’t let the bad thyroid slide, you know we’ll do Lugol’s iodine, we’ll do some vitamin E, we’ll do selenium. You know, I tell everybody, this is not a hormone clinic. You know, if you could, if, if if the person comes in here looking just for hormones that’s not, here we practice medicine and we’re looking to balance the system. So, you know, you’re, you’re a top competitor and we do take some care of some of the biggest, some of the biggest fights you have seen in these last days. And that you will see coming up with talking about the biggest ones where we’re helping a lot of these clients, obviously respecting all WADA guidelines world anti-doping agency.Â
So IGF one does not apply to them, but you get amazing what you could. You’d be surprised.And I would love to explain more on these protocols, what you can do with an athlete to naturally raise their hormone levels with the fixing leaky, fixing sleep, fixing micronutrient deficiencies. You fix these things, all of a sudden you do see a little boost in the testosterone going from a good I, I’ve never seen and this is sad, I’ve never seen an NFL athlete ever. And we’ve had about maybe 20 total come through here ever with proper testosterone levels that weren’t red, all of them low.Â
So it tells you something, right? So anyhow, so for a 45, 50 year old, man I always tell our clients symptoms of high hormone levels are very similar to symptoms of low hormone levels. There’s no need to go too high on hormones. And, and I’m, you know, I’m 36 years old, you know I was trying to pass what the 70 something year old but fine, I’ll tell you my true age, 36. This is a business you want to lie about, right? You wanna lie about being older. So regardless, I, you know, I guess, cause I’m a young guy and if you’d like to see, we have a gym inside our clinic we have a DEXA scan over there. We, it’s a very nice clinic. And we see so many athletes sometimes, you know we’re taken as, Hey, you’re you guys probably pro, very high levels of no, absolutely not. I’m also very against using any any hormone derivatives for athletes. I, my, our promise to our clients is give us our your blood will give you back better blood.Â
You know, for the most part, obviously can’t guarantee the whole thing, but that’s our goal. So if we use any type of testosterone it will be the bio identical testosterone and nothing else and nothing more. And we’re gonna go with a new 45, 50 year old men. We’re probably going to do perhaps either a 0.5 once a week or a 0.3 split twice a week. Something like that. No, no more than that. I’m not even a big fan of the 1 mL a week. Yeah. So we’re, we’re, we’re going to keep it right there. I, myself, young guy I’m doing about 0.3, 0.35 twice a week.
Mm hm, okay. You just kind of mentioned that you already gave me the answer on this one, this whole category of SARMs. What is your take on that? The harm, the harms, what are useful in this category?
Yeah. The selective androgen or estrogen receptor mod, you know, after going through medical, I still don’t know if it’s androgen or estrogen receptor modulators. So many people say it interchangeably, but you know I guess let’s say estrogen, just because that’s really more pinpoint on what they’re doing. Right. So like look the colamafen’s and so forth. I mean, it’s, it’s a growing topic. First, there’s a lot of confusion in regards to that. I’ve heard people say, for example, not that we even come close with any of this stuff but some of these PPR gamma inhibitors and so forth that they’re calling them.Â
SARMs, it’s not, SARMs like the the cause of the Carterian’s means and Austrians. And yeah. So if, if we’re speaking in regards to that that doesn’t even come, we only use here what’s in the body or what’s in the earth. We don’t use any, any other thing. That’s my, and that’s why, you know, I say this humbly why we’ve grown so much, even with our athletes because they know we’re not doing any kind of funny business. And like I said, for example, IGF it’s in you, you want you want to impact somebody well in their health and longevity. I mean, if I decrease morbidity in you by 50%, I’ll increase lifespan by 7%, right.Â
Roughly from what I remember from, from med school or, but so if I’m helping to decrease sugar levels with the IGF but also increase your performance abilities, et cetera you know, that that’s where we want to be. So a lot of these SARMs, I mean the only one we’ll use will be like a Clomid with an HCG on a 28, 29 year old that, you know does have, you know, a testosterone of, I don’t know 250 is showing symptoms or even 300, you know and he’s showing symptoms of, you know, what happened to me? I had a big hormonal issue, you know, where you’re tired you just don’t feel yourself. You’re working out the weight’s coming on and like crazy. You can’t sleep, sex life is out the window or going in that direction. So HCG with Clomid for us is about it’s about it. You know we won’t really, with these other things they call SARMs we’ve we haven’t, we have no experience.
Okay, perfect. And then you also mentioned the inflammation which it has really is the guiding almost theme of our whole summit. Every speaker’s talking about inflammation. So I’d love to talk about how do you, how does this fit into your, into your framework?
Right, so when I tell the clients what we do about controlling these pillars I always tell them then how we do it, right? So I call it the four R’s. We remove, replenish, reinoculate and we do recovery, right? And the first R, which is remove is the removal of inflammation, right. We work a lot with businessmen and, you know I tell a lot of them, I’m like, “Hey, if you buy a new company, what are you going to do?” The first thing you’re going to remove bad employees. You’re going to remove certain departments that aren’t working. You’re just going to clean house.Â
Well, same thing with us, we constantly live inflamed, right? Inflammation, with auto-immunity for example, Alzheimer’s first categorize it by 19. And by Dr. Lewis, Alzheimer’s in 1906 in Germany, right? And these inflammatory states, right? Leading to even auto immunity here, we do a test from Cyrex Laboratories, which is a predictive auto-immune which can show up to 10 years clinical symptoms before they actually manifest themselves. We’re looking to help the clients a lot with not to come to any auto-immune state. So one of the things we do, we look, we’re looking for leaky gut. We’re looking for blood-brain barrier issues, especially with, you know, people have had TBIs and so forth.Â
We’re looking for also parasites that can lead to inflammatory states like our beloved Canada, right. You know, but with the sugar and the, you know that’s a big problem here. And also some of the topics that we touched on with the chemicals, et cetera. So the removal of that inflammation for us is paramount. Before moving forward with anything, we actually start with inflammation. The first thing we’re looking for is inflammation. Before we look at glycation, hormones, et cetera it doesn’t make it, you’re building a house, right. You have to set all your pillars right. And then the first thing we want to do here is assess inflammation. That’s the first thing for us.
How is that done with blood tests? You said this what’s, that that’s a lab test that looks at a company, the Cyrus Labs that does that. Some biomarkers for inflammation.
Yeah, Cyrex Laboratories. Yes. They’re to me, they’re the Dr. Mark Hyman uses them too, as far as I know. Yeah. They’re there, I love those guys. Yeah. The medical director is Dr. Mark Edelman. He’s an 80 year old genius. And you know, we look at a lot in foods. We look at polyreactivity of foods. We, we, we go deep into looking at that to that person’s physical triggers of immune response. I use that term a lot. So what is triggering your immune response? Because as you voyage through your day to day you will encounter parasites, pathogens, food antigens a bunch of things that will trigger your immune response. You keep exposing yourself to, that.Â
It will lead to inflammation, will lead to auto immune. So what we’re looking to do is to understand really not only, and this kind of ties in with the epigenetics, right? Because your environment is really dictating much more than we thought until we calculated the human genome, right. And so inflammation plays a huge, huge role in that. So we try to be as data-driven as possible to get, get those, the diet, those markers, and and adjust them for the client over the course of three, six, and 12 months, over the year.
How do you monitor them or you recognize the type of wearables or how you, you know approach .
Oh, I totally didn’t get that. Can you say that one more time?
Yeah. Yeah. Sorry. You cut off. Are you recommending type of wearables to, to your patients?
Oh yeah, yeah, yeah.
Any wearables like anything you can track how they’re doing sleep and walking.
Yeah, I don’t have on mine on right now but I always we’re big on WHOOP. We use WHOOP a lot. Yeah. I love WHOOP. And we’re on Dexcom, the CGM.
Yeah, yeah, yeah. Dexcom. Excellent. That’s interesting. Yeah. That’s awesome. And are you using any type of, what are your thoughts about regenerative type of treatments, like Exosomes or stem cell infusions like that? Any luck with good results with this?
Our medical director, Dr. Richard Silva, he, he’s big on, on amniotic fluid, with the Exosomes and so forth. So we’ve been using that. It’s successful for most people. Some people, it doesn’t work and, you know, just give them their money back for those that immediately it doesn’t work. And that kind of works well on the business side but stem cells, we, we don’t have any experience with it. I am fond of, of it a lot, just because of regulatory environments, a little, you know we haven’t even ventured into that world.
Okay.
But yeah, I am super fond of it. Like I wish it wasn’t so.
How do you, how do you determine if a client this is the right fit for them? Like, how do you, what would you tell somebody who was saying, you know, I wanna, I want to work on changing my life and, and, you know, living at the top of my peak performance for longevity, how would they know that this is the right thing they should be doing or are they at right, do they have the right mindset? What type of, what did they have to come to you with already done? Is there any type of homework they need to do?
Just mindset. I’m very quick here to also get rid of clients that don’t have the right mindset. Like Tony Robbins talks about. Sometimes you have to fire your, your, your clients. And if the mindset’s not right, if they’re not willing to be on a regimen, and if they’re not willing to be compliant with the testing that they got, and you know all of a sudden, if it says they can’t have their eggs and whatever bacon in the morning, you know we expect them to be compliant. If they’re not compliant, I really don’t want their money. I don’t want their time. It’s just more that if the mindset is right if they want to be transformational about their lives we’ll walk with them the whole way through. Yeah. It’s mindset.
What do you, what would be the, if somebody is interested in learning more about your type of practice, where would they go for that? Where’s the information for that?
Wait, where would they go to learn more about what we’re doing?
Yeah, exactly.
So learn more in specific to what we’re doing or learn or say, somebody go to another source of reference where they can find more information on our.
About your four pillars, working to learn more about the framework? Yeah. They want to become a client. Where should they come to, where should they go?
Yeah, unfortunately we don’t have a lot of marketing out there. We do have our website, which you’re more than welcome, but we’re working on it avidly. I am very grateful. We’ve, we’ve never had to market a day. We grew through word of mouth, a hundred percent. Our agendas are full. So it’s more, you come into our nice facility and, you know we sit down, we, we’re the type we like to sit down with our clients, cross our legs ask how the kids are doing, you know, talk a little bit over some tea and so forth, you know, and yeah most of the clients either they set up a zoom call with us or they come in and, you know, we can go from there.Â
Our, our website doesn’t have that much information. That’s something I want to change. And usually I direct people to certain podcasts. Joe Rogan’s been doing some podcasts in regards to this, Dr. Mercola, big fan of Dr. Mercola, Dr. Mark Hyman also has some cool information, you know? So especially these clients that are just walking in and you know, they have their traditional doctor giving them you know, perhaps, you know, a nice cocktail of some polypharmacy that they’re trying to get off and make some lifestyle modifications. You know, I, I try to guide them through other more stronger sources that have been in the market longer than us, but I I’m working on that. I’m working on getting more of a stronger online presence.
Right. What does the next 12 months look like? What do you, what are you excited about some changes that are going to happen in your field of work you’re doing? Where do you think it’s going now? Like this it’s really what I call precision medicine which you’ve been talking about. Where do you see it going?
I honestly think this is the future. I do see an increased awareness in many people, especially now with after COVID where people are becoming more curious about their health and what they need to do to improve their, their health. So I definitely think that for us in the future, I’ll, we’re here specifically we’re going to incorporate ozone therapy, hyperbaric oxygen chambers, et cetera. And just some strategies. Intravascular radiation too, a little bit of that. But overall, I think, I think in the next 12 months a lot of the world is going to continue on the course that we’re on right now. I don’t think anything specific is going to happen but I think there’s just a bigger and bigger movement of health awareness than just not, Hey, take your pills, right?
No, that sounds exciting. Okay. So that’s it. This is great. Thank you so much for your time today, Dr. de Andrade. I really appreciate it.
All right. Thank you. Thanks for having me.
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