Welcome back to the Reverse Alzheimer’s Summit. I’m so excited to have Dr. Kelly Halderman here with us today. She’s a researcher, author, clinician, consultant in nutraceutical formula. She’s got a lot going on and she completed her family practice medicine internship at the University of Minnesota. She has a naturopathic medical degree from Kingdom College of Natural Health, where she is the current academic Dean of students.
She holds a certification in methylgenetic nutrition by the NutriGenetic Research Institute, and has a certification from the American Functional Neurology Institute in functional neurology and neurofeedback. She is an active member of the American Academy of Anti-Aging Medicine, president and founder of the American Association of Nutraceutical Formulas, as well as a member of the American Medical Association and Physicians Committee for Responsible Medicine.
Dr. Halderman is also board certified in clinical nutrition by the CNCB. Has certification in plant-based nutrition from Cornell University and a health coaching certification from the Institute for Integrative Nutrition. She has tons of training that is really important for us to understand when it comes to Alzheimer’s disease. One of the things she specializes in is Phase 2.5 detoxification, a phrase that she coined, which involves properly restoring biophysiology. This is our body’s built in toxin transport system, and she has successfully developed novel nutraceutical products and clinical strategies to support this important, really essential phase of elimination. Dr. Kelly Halderman. Thank you so much for joining us. It’s a pleasure to have you.
Thanks, Dr. Heather, I’m so excited to be here.
So I wanna dive into why this, especially this Phase 2.5 detoxification is specific and really relevant to Alzheimer’s disease.
Absolutely, you know when you asked me to be on the summit I thought, what an important topic to really, to reach people now whether you’re in the stage of have Alzheimer’s, whether you have family members. We really wanna make sure that Phase 2.5 is optimized. So in a nutshell, if I had the audience members in an elevator, I would say that bile flow as you just said, Dr. Heather is our body’s inherent way of getting rid of toxins. We know that we’re living in this completely toxic world, I mean, there’s thousands of chemicals that we’re exposed to on a daily basis; air pollution, the water system or foods.
Unfortunately, detoxification in the words of Dr. Klinghardt, who is one of the best doctors on the planet. He said it used to be his hobby, like, “Oh yes, it’s my hobby to eat really clean and detox.” He says, now it’s absolutely essential for life. It’s absolutely essential that all of us learn how to optimize the detoxification, the getting rid of these toxins. And that’s really what Phase 2.5 is all about. Phase 2.5 is about optimizing, maintaining the bile flow in your body, which let me tell you, I didn’t learn about this in medical school. I did not know how to optimize this whatsoever when I was 20 years old.
I had my gallbladder taken out because I complained of some abdominal pain. If I would have understood biophysiology. If I would have really understood the downward effects of what that was gonna entail. And I’m not saying that if you don’t have a gallbladder, I’m not saying, excuse me you’re screwed. Because you’re not, you’re not screwed. All let’s keep listening. Keep listening to this podcast. What I’m saying is that this inherent mechanism, this God given flow of bile in our system, it really is not appreciated. It’s not appreciated by even I don’t think the best doctors. I think we’re really under starting to understand it of all kinds of practitioner understanding it.
But today I’m gonna teach you easy strategies on how to know maybe if it’s not working to just make sure that it’s optimized, because again, you wanna be in the mindset of prevention. We want even if we really actually have disease, because I will tell my story in a very quick way is that when I was practicing medicine I started to have all these very strange neurological symptoms. And I was diagnosed with MS, multiple sclerosis. And I was given pharmaceutical medications, told to go home and be with my family and my children. I was given a death sentence.
And really, I didn’t understand what was going on until I got to the root cause. And I will say one of the subtypes of the cause of Alzheimer’s by the work of Dr. Dale Bredesen is a toxic overload. And so a toxic overload it could be from a Lyme disease, HSV. There’s things in our system that will cause amyloid to form. And amyloid is actually anti-microbial. I had Lyme disease. I found out I had Lyme disease root cause of what was going on. If I wouldn’t have found that out, of course, I probably would have Alzheimer’s. Of course, I would be that person because my body, my brain was reacting to the stress. My brain was reacting to that. Let’s really educate right now in this next hour we can and how we maximize our body’s ability to not have to create amyloid, not have to create cow proteins.
Kelly, if there’s anyone doubting how important understanding detoxes for Alzheimer’s. I can say that of the hundreds of Alzheimer’s patients that I’ve seen in my clinical practice, 100% of them have high toxic burden. Now whether that’s lead, mercury, other heavy metals like arsenic or cadmium, or it’s mycotoxins from water or damaged buildings or chemical toxins, like glyphosate or parabens, PCBs pthalates, the other chemicals associated with exhaust, fuel exhaust. The things that we can measure 100% of our Alzheimer’s patients have elevated numbers of some and sometimes even all of those things. And so I do a lot.
I spend a lot of time in my clinical practice educating about the different phases of detoxification. And I love that you call this Phase 2.5, because we know scientists and medical doctors are always talking about Phase 1 and Phase 2 liver detox. Well, we don’t always talk about what happens after that. So the liver has to work with the gut and I think of bile it’s like this toxic sludge that your body forms. That your liver, like you said, like this God given divine design, your liver is so much work to get rid of that toxic sludge called bile. But it needs the help of the gallbladder.
It needs the help of the gut. And so making sure that we actually eliminate, we don’t just do all the work of detoxification in the liver and then it sits around in our gut, in our like where does it go? Bile is so important. And bile flow is so important for actually eliminating, getting it out of the body. So let’s jump in. And also I wanna mention, wow, you were diagnosed with MS and here you are super successful doing great work in the world, and that’s a neurodegenerative disease. This is neurology. When you go to neurology they talk about MS and Alzheimer’s, and Parkinson’s, and Lou Gehrig’s, the ALS, These neurodegenerative diseases we type them, we diagnose them in the medical community based on a set of symptoms. But when we take that step back and look at root cause a lot of the same causes ends up manifesting a slightly different symptoms in different people. So MS is it gonna be that different from Alzheimer’s? Sorry, go ahead.
No, it’s absolutely they say that old adage in neurology is diagnosed and adios. Here’s your diagnosis. I’m sorry, there’s not a whole lot we can do for you. Go get your affairs in order. It’s so black and white. And Heather, you’re saying exactly what I’m saying is that we go into the doctor, let’s say we have a fever. We go into the doctor and we have a fever. They don’t say you have a fever, put a period at the end. They say you have a fever because of, right? That’s the exact same approach that we used to be using with Alzheimer’s. It’s not, you have Alzheimer’s period. It’s you have Alzheimer’s why? Let’s go explore why. And that’s where functional medicine comes in. And that’s where we sometimes need to seek out help.
We really need to optimize that gut. We need to have someone who understands detoxification on maybe a better level so that they can really help you. But I’m gonna give you some tips things today that people can do to just start to help to optimize the biofuel. But I think that’s important is that we’re surrounded by all these demented genes. You talked about it, mold, HSV. In the brains of Alzheimer’s patients on autopsy they find at times they find pathogens from poor dentition. From mold issues. So again, it’s really something where we have to take a holistic view and not put a period at them. We have to really figure out what the root cause is.
Tell me more about bile flow. Just describe the anatomy.
Let’s do this really simplistically. So I have some teenagers now, they’re always like, “Mom, what do you talk about when you’re on these podcasts?” So I’m like, “Okay, well, let me just break it down for you guys.” So detoxification a process that you don’t have to control. You don’t have to think about it. You don’t have to tell your heart to beat. You don’t have to tell your liver to start making bile.
You don’t have to tell it to start detoxification, but in your blood, there’s things that need to be excreted. And those can be indogenous. So like leftover thyroid hormone, leftover cholesterol, metabolism, metabolites, or they can be exogenous, xenobiotics like, we just rattled off, VPAs and heavy metals, and things that just do not belong. So they’re in your blood flow. And they’re gonna go into the liver cell just for simplicity terms, because we have detoxification and pretty much all of our cells, our kidney is a workhorse, but really the main one is the liver. So the blood flow will go into the liver, into the hepatocytes, that’s a liver cell. And Phase zero is actually the transport of that toxin into the liver cell, that’s the number, that’s actually the first one is Phase zero. And then Phase 1 is where that toxin is made a little bit more toxic actually.
It’s made a little bit more reactive because the goal is to get it to be water soluble. So it has to get a little bit more reactive. So hydroxylation, oxidation. Those are all Phase 1 reactions. They rely on vitamins, and minerals and all kinds of sulfur, really good stuff that could usually come from our diets. Sometimes we wanna increase those nutrients to help with Phase 1. We can actually have I can give you a paper that was published that shows foods that help with specific Phase 1 enzymes. It’s really cool, and so you can kind of look through it and make sure your diet is hitting like all of these great things. So I’ll give that to you so we can have everybody see that. So then when the toxin is made a little bit more reactive and not every toxin needs to go through Phase 1, but it will get passed off to Phase 2.
So Phase 2 detoxification is things like glutathione comes in. So you’ll have a glutathione conjugation where you’re hooking on glutathione so that you’re salt fading it. You’re methylating it. All these words we’ve heard before. So what you’re just doing is you’re making sure that toxin becomes water soluble because your bile is 99% water. So I would suggest everyone take hydration very seriously for the millionth time. It’s like, “Oh gosh, if we’re told to drink any more water.” But really if we’re dehydrated, your bile, it depends on you being hydrated. So the toxin then goes through the other side of the liver cell to get to the bile flow. ‘Cause that’s like the evacuation area.
The movement of that toxin into the bile flow, it is not Willy nilly. So that’s what we call the Phase 2.5. It needs a lot of things. It needs a lot of things to go right. A lot of things to shut it down. So this movement when your toxins all ready to go, it won’t be able to get into the bile flow if you’re inflamed, if your gut is bad, if you have deficiencies and phosphatidylcholine, which we’ll talk about. If you’re not making your bile, you’re not making your bile acids. And again, there’s things that nutritionally that you can do to help and I will talk about those. But so if Phase 2.5 isn’t working, you have a toxin that’s wanting to get out into the bile flow to get to the toilet. But it cannot. Let’s say like you’re inflamed and have a bad gut. And the toxin is like, “I can’t get out.” It’s like not being able to flush your toilet. So the toxin, which has been made a little bit more reactive will go back into your blood.
Where it just has free rein to go wherever it wants to go and toxins like fat. What’s your brain consist of? It’s a fatty tissue, right? So this is kind of I’m gonna go on for the very small tangent, but people always ask me, what does Phase 2.5 have to do with weight gain? What do you mean toxins and weight gains. Well, guess what guys, when that toxin goes back in, your body goes, okay, we have an emergency. We need to keep the fat on the body, because the fat is gonna house the toxin that went back into the blood. So of course we can’t lose weight because the body is like, “If we lose weight, we lose our protective mechanism for these toxins.”
So but the neurodegenerative part of that is that then you have these heavy metals, everything is going back into your blood when it shouldn’t be going into your bile flow through your intestine, keeping everything nice and acidic, keeping that gut really happy and those microbes in there are rarely happy. The pathogens don’t wanna live there and everything. And it stimulates the migrating motor complex. So if you’re constipated, that could be a sign that your bile flows is not working. So I kind of digress but once the toxin, if everything is working well the tube to the Phase 2, it will go in and then so that Phase 3 is considered bile flow to the toilet. So that’s like the perfect world is that then it’s all working exactly the way we were designed.
What sounds a little scary there is how you mentioned that inflammation is one of the things that can prevent this from working well. Well, if those toxins then go back into the blood, it’s almost a self perpetuating cycle of now you have more toxins in circulation. Now you have more inflammation and now you’re even having even harder time getting rid of these toxins.
Absolutely. So I think it’s really interesting when I talk about inflammation, even in front of these brilliant doctors groups. When we have seminars and things and you think about inflammation it’s so esoteric. It’s so like, “What do you mean? Okay, yeah I can test my CRP and yeah.” And I’m like, “Let me show you the most important tool that you can ever use to really help you manage your inflammation and hold up a fork.”
Fork, I love this.
This is it. This is it, this is what you can do to make sure that you’re not inflamed, every bite of food that we’re taking in, I mean, there’s a lot of other things, but really for simplicity terms, what are you eating? What are you nourishing your body with? If it’s a lot of processed fats and things that you can’t pronounce, I just screenshot. ‘Cause my middle child likes Lucky Charms, which I don’t buy. But every once in a while seem is that I just screenshot from The Food Babe, what toxins are in Lucky Charms, carcinogens, and all these dyes and I mean talk about neurological insults. I screenshot it and I sent it to him. He is like, “Interesting.”
If I had to say one thing about inflammation, it’s like, it’s really in your hands. Yes there’s like predispositions that we have. People say, “Oh, it’s in my genes.” And it’s like, you know that’s a little bit about epigenetics what plays the genes, what controls them? I would say number one is dietary. And our brains are so sensitive. There is a type of Alzheimer’s that has to do with diabetes with how, if you’re not managing your blood sugar, if your insulin levels are high, that you’re actually, like creme bruleeing your brain with this glycosylation. So it’s like, I really think let’s just like dumb it down and just focus on things that you don’t have to read the labels. And we hear this over, and over, and over again. But wow, is it important? It’s never gonna go away just like water. You’re always gonna hear another reason, another reason to drink water.
And eat well. One of the things that comes up with my patients also is that the brain games, so people ask, well, what about Sudoku? Should I be doing crossword puzzles? I’m like, “No, just figure out new recipes, go to the store, shop for new types of foods and make them.” Because that is like not only you’re basically saving yourself a ton of time because you’re gonna have to do that anyways. You’re gonna have to change your diet. And that is brain exercise.
To learn new habits around food is exactly the type of really important brain exercising and neuroplasticity, creating new pathways in the brain, around your habits, around food, around shopping. What lanes do I go down in the grocery store? Or maybe I should start going to a new grocery store. Maybe I should chop these vegetables differently. Maybe I should bake them instead of fry them. Thinking through all of these new things and creating these new habits actually helps with neuro-plasticity. And in addition, you get this incredible benefit that you’re talking about that, really if we could bottle that, if we could get the benefits of really good high-quality food, if we could get that in a pill, Oh my gosh, but we wouldn’t have jobs. But alas, it’s a little bit more challenging than that, but that challenge is also beneficial.
Absolutely. I totally, I totally agree with that. That is very insightful because I love sulforaphane. For example, it’s in the literature. You can get it on Amazon, but really the best place to get sulforaphane is from broccoli sprouts. I mean, that’s the creme de la creme. So I have an exercise where I give people PDF on how to grow broccoli sprouts. Because it’s like, what better way to get this amazing nutrient that actually will help Phase 2.5 open up. It’ll decrease your inflammation. You’re getting like the twofer, you’re getting like the, oh my gosh, I gotta buy this and water this. And they’re getting that brain exercise. And they’re also reaping the benefits of this wonderful nutrient.
So excited. Our artichokes at Marama at the residential care facility are just about ready to be harvested. And artichokes are in the thistle family, which is also really great for liver support. And I don’t know, maybe you can tell me, are these sulforaphanes directly good for bile flow? Or is that where we were wanna focus on things like hospital choline?
So the stabilization of that transporter that takes that phase 2 conjugate toxin and actually pushes it through, think of a tunnel. There’s gotta be a tunnel or a door, stabilization of that MRP2 transporter is actually done by sulforaphane. So your door that you can get the toxins out really love sulforaphane. It really loves to decrease your inflammation. Milk thistle also the thistle family will also help stabilize that MRP2 so you can get more of the toxins out. I love artichoke, I actually learned about that working with the Amish, who are just fantastic with teaching me so much about food and how it works.
That actually has some, I always mess up this word bile-agog or like secrete-agog, where it’s literally like the squeezing almost of, ’cause there’s actually little muscles around all these bio canaliculi. So you literally need these little muscles to really squeeze that bile out, so artichoke also has that property in it. And then that being said, bitters. Bitters are something that are really underappreciated, I think underutilized in that the bitter herbs will also help the bile flow and also helps support the liver. So your dandelion, that’s actually my favorite one to help with that stabilization.
So some good like plant based bitters or dandelion, jensen, it’s sort of normal here and usually come in a taster for him but dandelion greens, just even a little bit, even Arugala is a little bit more bitter. Some of the endive and some escarole, some of these more bitter greens are helpful and we have, again, all of them growing in the Marama garden. And the other thing with artichoke is you often are dipping that. Usually it’s olive oil, and some garlic. And so garlic and the onion highly sulfur containing foods that most people are tolerate pretty well.
Oh yeah, absolutely. And that kind of reminds me of a mistake that people often use is and when I had Lyme disease and I was literally bedridden, I was seeing some fantastic practitioners, but they were really loading me up on Phase 1 and Phase 2 pushers, supporters. So just think of this, my door is closed. My toxic door was closed because I was inflamed. My gut was inflamed. I didn’t have phosphatidylcholine on board and we’re gonna talk about that. Hang on one second with that one. But phosphatidylcholine makes our bile flow.
So everything in our body that flows so if you’re a woman you’ve ever had a plugged milk duct when breastfeeding that’s a clue that you might have phosphatidylcholine deficiency because the government says 75% of us do, especially for us breastfeeding women. We really need that phosphatidylcholine onboard. Anyhow, if you have responded negatively to a detox. Let’s say, someone put you on a bunch of Phase 1 and Phase 2 up regulators probably ’cause your Phase 2.5 door was shut. And then your toxins went back in your blood and you felt worse. I have seen people really do themselves harm with doing that. Like, I’m gonna take a ton of glutathione. I’m gonna take a ton of NAC. I’m gonna take, and then there it backfires. And then well, that’s a clue that the Phase 2.5 is not working. Lots of other things that I’m just gonna kind of rattle off real quickly that may signal that your bile flow is not working. Because bile flow is involved in thyroid physiology, cholesterol metabolism, again migrating motor complex, if you have constipation issues, it also has some other endocrine signaling if ever had SIBO.
You know, really there’s so many things that can, in my mind, I think while we better make sure Phase 2.5 is optimized but if you’ve have a history of cholecystectomy means like your gallbladder was your biophysiology was shot to the point where like you had to get your gallbladder out. That’s a big clue. But there’s a lot of other things I have the whole list at drkellyhalderman.com in my website, if you wanna take a look at that. But just a lot of different things and people are very surprised to learn that biophysiology and having that flow optimized even, I mean, I did not learn that it had to do with thyroid physiology. I did not even, I am a medical doctor and I didn’t even know that, so a lot of these things, I think when you go to your regular doctor, they are doing the best they can. They are working inside the constraints of what they have learned in the protocols. My husband is a medical doctor. I mean, they do amazing things, but sometimes like, you know, digging deeper in from a naturopathic standpoint, from a root cause protocol, I think that’s super important.
So down the moment everyone has been waiting for. Where do we have phosphatidylcholine?
Sure. So the best place to get it is eggs, beef, almonds. A lot of people have problems with those foods. A lot of people who have gallbladder issues don’t do well with eggs. There’s some people who are vegan, and vegetarian, and they’re not gonna do meat. And some people just don’t do well with nuts. That’s just not their thing. So you can supplement really there’s a lot of really good options. I really have found that sunflower, sunflower is really high in all the phosphatidyls. So not only do you get phosphatidylcholine that makes sure your bile is flowing. Because in order for that toxin to get out the door, it needs to be moved in the same movement, it depends on the phosphatidylcholine.
So you can, again, supplement, just be wary of a soy because I really, if this is non-GMO, I still think like there’s better sources that’s why the sunflower, the sunflower is more complete again phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol. So you have all your very important phosphatidyl and that’s just so important. There’s just one key thing. Think about the phosphatidylcholine. Think about talking to your doctor about supplementing, making sure with your licensed health care provider of everything I’m saying that’s something that’s appropriate for you or increasing those foods if you can.
And so with sunflower, did you recommend like sunflower seeds? Can you just go to the gas station and pick up sunflower seeds? Or is it sunflower lecithin, or sunflower oil? Like what’s the best source of sunflower choline?
Sunflower lecithin is what I prefer. Professional health products has a sunflower lecithin powder. It’s white, it’s tasteless. Actually, it’s kind of got a little bit of a nutty flavor. I’ll just use a scoop of that a day in with my other stuff, the greens and things. And I’ll take that, so you know.
You sure can, you can definitely put it in a smoothie, yep.
about these choline groups is that you don’t need to take them separate from other things, a lot of the other detox things we talk about, it’s really important to take them far away from everything else and that can feel so overwhelming for someone that’s like, oh, 30 minutes before a meal and two hours after. And all of these things, I think that like supplement contortionism. So you’re having to put all these different things in different spots in the day, but this is a great way to help detox. And you can just add a scoop of it, to whatever you’re already doing, your smoothie in the morning, or your whatever. Could you put it on like in salad?
You can, the instructions say to sprinkle on things. So I will sprinkle it on like oatmeal and things, and put like some extra nuts on it. But I think people get pill fatigue, and they get where they just don’t wanna do all these potions and lotions in it ’cause it’s not natural. It’s not natural for us to have to be grabbing. But I feel like if we’re using food based supplementation, nutritional things, it’s more natural to be like, “Oh, I can put this in my smoothie. I can put this on my salad. I could put this on anything I want to like enhance the flavor.” So again, it’s always been my mantra, food is medicine 100%.
And supplements are supplemental.
I forget who it was with the potty mouth that says you can’t out supplement a shitty diet.
You can’t make up for eating junk by supplementing. So really it does start with that foundational piece of getting really good food in and being a little bit strategic with some of the things you talked about that can enhance and do the supplementing for you of those sulfur compounds, the things that support glutathione and Phase 1, Phase 2, and Phase 2.5 detox.
Absolutely. And then I think we should probably just mention is that when you start to move your bile appropriately. Let’s say you’re really gonna take this seriously. And you’re gonna try and have a better diet, and you’re going to maybe do some sulforaphane and you’re gonna get on some dandelion herbs and things in your phosphatidylcholine. You’re gonna have a bile that has a lot of toxins in it. Because that’s what it’s designed to do. So where that bile goes is into your small intestine and it goes through your colon and then it should hit the toilet. A lot of times, if we haven’t optimized our digestion, if we’re not going to the bathroom, we’re not having a bowel movement daily.
What can happen is that the bile gets to the colon, but then there’s enterohepatic recirculation. Those toxins desperately don’t wanna end up in the toilet. So they go back again and it’s like, they just don’t wanna leave us alone. So people will use binders. Now we’ve heard of intestinal binders and binders will bind. That’s like insurance policy. It’s like your livers work so hard to get those toxins in and your Phase 2.5 is working and that in the toxins are in there and your brain is happy, and everything is happy. And then they get to your colon and they’re like, “Well, we’re just gonna go back.” It’s like binders are a strategy that some people, there’s people who are more knowledgeable about binders than me, because I mean that’s just their whole strategy is using them. I’m judicious because binders will bind your medication.
They will bind a lot of other things. Cholestyramine is a medication that people that is prescribed, but it can also bind like minerals and things that bile acids and things that we need. I don’t give a blanket statement to anybody, but again using binders is something that I think you wanna talk to a person, a savvy practitioner about. But certainly with an onslaught of toxins moving out, like when I’m really gonna hit detox really hard when I’m actually gonna try and rev it up a little. I will use binders at nighttime. I will do that.
And we’re so lucky because we’re gonna talk to Dr. Neil Nathan, Dr. Nafisa and Dr. Joe Krista all about and Dr. Margaret Christiansen. So there’s a lot of other really great experts on the summit. You just click on their talks and to learn more about binders.
Because I think refers to them that’s amazing.
You bring up such a great point about balancing these things and just the way you described the bile flow being sort of at the end of the liver’s job, it’s gotta get, you don’t wanna back things up. So if you have a block in the road, then you start releasing things upstream, you’re gonna end up with this flood of toxins. And the analogy I use is like a river valley, but like with the stream flowing to the ocean, if you have a dam and then you start releasing everything from the top, you could just have a destructive flood. And so what we need to do is open up elimination and that’s sweating, bowel movements and urination, and exhaling. That breath out is another great way that gets forgotten about in detox. But if we have, if you’re not having a regular daily bowel movement, then we need to be, I think, like you said, cautious about how we open things up upstream.
Absolutely. I’ve really seen that order reversed and problems happening. So it’s like, number one you have to optimize going. You have to optimize evacuation. You have to make sure you’re having those bowel movements. ‘Cause again, it’s not gonna work. It’s just like, that’s the whole mechanism. So it kind of goes backwards. It’s like Phase 3 comes first, and I think with Phase 2 with 2.5, rather like you wanna make sure that you’re going to the bathroom. And that you’re also making sure that you’re really optimizing the bile flow. I feel like those can be just done in tandem because it’s not like if you start to push on the gas for Phase 2.5, it’s not like you’re gonna backfire as is if you were pushing on Phase 2 and then you’re like, your door is not open.
So I think that’s a good, very good strategy to remember is like we just have to optimize digestion. I love sun fiber, you can get it anywhere, Amazon. Everybody in my family is on sun fiber ’cause it nourishes the gut. It’s a prebiotic naturally occurring, it’s FODMAPs approved. It really helps to regulate out get the strategy going. Now of course I am a fan of functional medicine testing. I think that if you’re having issues, it’s really smart to go and really have some good quality functional medicine testing.
I like the GI map to look at what’s going on in your gut because LPS, so lipopolysaccharide from a bad gut will shut down your Phase 2.5 so fast. So fast. We never omit the gut. And the best thing you could do to help your gut is use your fork properly. So like probiotics, prebiotics using the food as medicine, reaching out for help if you have infections and things that are ongoing. I was listening to a podcast with Dr. Dale Bredesen talking about a person with Alzheimer’s and they found very, really severe gut pathologies, cleared it up, and the person made almost a complete turnaround. I mean complete turnaround. Reversing Alzheimer’s it’s like the brain we thought for so long that the brain we couldn’t do, it’s like the opposite of neuroplasticity, the brain if you have an insult it’s over, game over, it is what it is, that is not true.
Neuroplasticity means to change, to be able to mend again. Your brain, I would like to hammer home this point too it’s that, our bodies are doing, they’re doing what they’re supposed to be doing, there is a reason there’s a downregulation in an ATP and production. And it’s like, the brain is like hunkering down because something is wrong. There’s no period after Alzheimer’s. It’s like why, again why? And it could be a lot again, this could be a multitude of things, which typically is. But again, the blood sugar, the toxins, getting the bile flow, these are all so important strategies. Whether you’re a young person, all the way to people who actually have the diagnosis Alzheimer’s across the board.
One thing that comes up with gut a lot in my clinic is that people think, oh, because I have constipation, there’s no way I have a parasite. With a parasite, I’d be losing weight and I’d have diarrhea and this would be going on. And then what I find is lo and behold, someone with no gut sometimes no GI complaints ends up having a parasite. I mean, it’s just wild. None of this is textbook all the time, but it couldn’t agree more. It’s so important to check on what’s going on in the gut, because sometimes the symptoms manifest elsewhere including depression, anxiety, all kinds of neurological and mental health issues come up because of pathology going on in the gut.
And we won’t know unless we look. We can be so much more targeted, so much more specific if we have that data to help us figure out what the best treatment plan for an individual is. And we can talk about these concepts and strategies. And I think they’re good for the vast majority of people. But if you’re really struggling, it’s really important to go see someone and get a test like a GI maps done.
Dr. Halderman that reminds me of the importance of genetic testing because, we can get a little scientific here in that. That’s how I discovered Phase 2.5, because I was looking at a lot of genetics. I was looking at a lot of people with SIBO and really lo and behold, they were having problems with the manufacturing of their bile. And they were having problems with the manufacturing of their phosphatidylcholine, our bodies make it. There’s enzymes in our body that actually help make bile, that help make phosphatidylcholine. Some people have genetic differences where it’s a little bit harder for them to perhaps their enzymes a little bit different, and that can parlay a slowing, let’s say slowing of that.
So if you have some genetic susceptibilities, like I did, I have PEMT genetics SNPs up the wazoo, meaning that I don’t make phosphatidylcholine very well myself. So it’s even more important for me to actually supplement. Now when I was 20 years old, I really wish I would have had this information. ‘Cause I think I could have saved myself a very expensive surgery. And bile flow is actually linked to MS. There’s a paper that came out in Halloween of 2018 in the New England Journal of Medicine saying, bile acid and bile flow actually there’s a correlation with MS. I’m like, yes, I live in this body. Yes, I have experienced this. So I think that’s really important to kind of make sure that we’re looking at like all the genetics. And so PEMT. So if I see that, I will wanna make sure this person is taking their phosphatidylcholine. There’s really not a whole down a lot of downside, if any to taking the phosphatidylcholine, I’m gonna look at ACAT genes, A-C-A-T. Now ACAT enzyme actually is responsible for making your COA or actually it’s a responsible for helping process your fats and proteins.
I have a question about phosphatidylcholine. We’ve explored why this is so great for bile flow, but phosphatidylcholine is also part of cell membranes. And also the nuclear membrane in our cells. We might remember this from the phospholipid bilayers that we studied in chemistry class or biochemistry in high school or college. And one of the places where a lot of toxins get stored is in that cell membrane. So we’ve talked about getting things out through the gut, through that bile flow, from the liver, but in the periphery in our cells, in our fat cells in our brain cells, in our thyroid cells, in our lymph cells, everywhere else the toxin gets stored it can be in the membrane and phosphatidylcholine from my understanding has the potential to help release it from those places. So kind of like glutathione, it can work as a provocation agent. Have you seen anything around that? Does that feel true for you? Is it different if it’s oral versus if it’s IV. How do you think of phosphatidylcholine in that context?
So that is an incredibly great point is that, I studied the work of Dr. Andrew Heyman and Dr. Richard Shumaker and they are big fans of doing an oil change. So you really wanna be very, give a very robust amounts of these phospholipids, because just of what you said the toxins were there. Now I have seen where, when you’re using phosphatidylcholine I have seen where people experience like almost like a die off. Butyrate although it smells like cheese, butyrate can help burn those up for that when you’re doing that oil change. So again, that’s kind of a clinical tip maybe from some practitioners that if you’re gonna hit phosphatidylcholine and you really want, if you think this person’s completely, very full of toxins is that you’re going to have a replacement which is wonderful. Like you were saying, it’s every membrane in our body. And then you can actually use some butyrate to help burn that off faster.
Oh, that’s a super helpful tip. So you were talking about genetics and phosphatidylcholine. And I’m curious how would someone go about getting the right test? ‘Cause there’s a bunch of them out there.
Oh goodness, there are. I prefer the functional genomic analysis. So that’s something that a practitioner has to order because it has a lot, a lot of SNPs in it. So but a lot of them are for research purposes. So it’s kind of like if you’re a layperson, find somebody, go to the NutriGenetic Research Institute website, and look for a practitioner. So then they can use that report. So that’s pretty high level. I really don’t know off the top of my head of 23 And Me, I don’t know if they ask for the PEMT gene, their strategy and you know, there’s so many. What I’m gonna do is I’m gonna give you the genes that matter to me. And then maybe when you’re looking for kits and things, you can see if they’re on there.
So number one, which I’m sure you’re going to talk about is APOE What’s your APOE set? So I’m not gonna beat that with a dead horse. You’re probably gonna have a whole and watch that everybody just watch it. It’s gonna be amazing. And then PEMT. So again, that’s responsible for making your phosphatidylcholine. And I will say this as is just because if you have perfect PEMT genes does not absolve you from taking phosphatidylcholine seriously. And then the ACAT, so ACAT is responsible for processing fats and proteins. It’s really important in terms of Phase 2.5 regulation. So you wanna make sure that if that’s something you’re having problems with, you may need extra digestive support.
You may actually need more help with processing fats and processing proteins. Pank P-A-N-K, Pank is responsible for making the building block, the COA of a acetyl-COA. So acetyl-COA has many pathways that it goes in the bile. Thyroid hormone formation, bile acid formation. It’s just like the top building block. So if your pank is not working, you’re not gonna get the COA to make all these, that downstream metabolites. So pank, when I see that, I just suggest to people that they explore taking pentacene. Pentacene is a really great cheap nutrient that also has helps with a lot of other things as well. Including cholesterol metabolism. So those are kind of the genes I look for now. If you wanna get really deep in the woods, you can look at your ABCC2 genes. Those code for the door that get the toxins out. So you can look and see, do you have a big door? Do you have a big door where all your toxins just go on out? You know, just like think of like the fire alarm goes off at Walmart and everyone’s like running out.
Like your toxins are running out, so do you have a big door? That’s great. Those are those blessed people who can like, we have all kinds of toxins and they just go out through a wall. If you have polymorphisms in your ABCC2, you could have a teeny little door to start with. So it’s like, you’re starting off with a challenge. You’re starting off with the enzyme that codes for that may not be as well suited to get all those toxins out. So there’s things that you can again, and we already went through those to help stabilize the I mean, to help make it work as well as it can. The milk thistles, the sulforaphanes and things. Lots of foods and things that can help stabilize that. So those are really, if you’re biohacking, those are always the ones that I like to really look at to really optimize this and there are more. But I think, I have done other podcasts where their practitioner base, The Better Health Guy has a really good podcast where I’m in it. And if you see, if you wanna get more information on that, I would go see that episode 79 on The Better Health Guy.
Excellent, excellent. So I want to understand a little bit more about your personal story. I know sometimes you start hearing you and you will alluded to it, but you had, I mean, this has been a huge influence on what you do and what you share because you’ve been through it, you get it. You’ve been diagnosed with a neurodegenerative disease. You’ve had your gallbladder out. So tell me a little bit more about your personal story.
Sure. I always start the conversation with people who are in my care with. I know what it feels like to be in a disease body. I know what it feels like to be told like there’s no hope. And that is what has driven me so hard to really use the brain that God has gifted me with to dig into the science because you, guys, it takes an average of 17 years for good clinical data that can help people that’s been published to get into your doctor’s office to help you. 17 years, we don’t have 17 years, right? That’s my passion is really going in finding the data, finding these things that can help us today.
It can help us prevent these staggering numbers of people who will be affected with Alzheimer’s. And use that data right now. So yeah, the neurodegenerative diseases. I was so ill that when someone would tell me what their phone number was, I would say what’s a seven? Like I couldn’t even figure it out. I couldn’t read to my kids. I am perfectly well able at memorizing an entire PowerPoint for an hour and getting up and talking. I mean I am living proof that you can reverse neurological diseases. You can reverse, your brain is designed to reverse just get rid of what’s causing it to do these things. That’s what I would say.
How inspiring, how long did your journey take? Like this doesn’t happen overnight.
No, it doesn’t happen over night, Heather. We know that and we also know that it’s daily. I didn’t just get better and then here I am. I mean, it was probably a good five years of crawling my way out of that, crawling my way out of the trenches I was in of just these diseases that I had no name for. What I knew my body was just not working. And I had to discover why, and I really credit brilliant practitioners just didn’t stop asking why. They just didn’t stop asking why.
And that’s why I think the naturopathic model fits me better as where I’ve experienced this is that. We’re just don’t diagnose and adios. You know that’s not enough. We have to figure out there are reasons why, reasons that we can help prevent, reverse, things like Alzheimer’s and let’s go after them. We know them, find a good practitioner, find someone who can help discover that. So that’s kind of like my mission right now is to just bring all the good clinical data and information to people. And no one is gonna stop me.
I love it. One of the struggles is that as we get people on a certain diet, or living a certain lifestyle, you wanna put an end date on it. Is okay, can I go back to my regular life? Can I go back to having my cocktails and watching the news and doing all these things that maybe I didn’t serve them, and just to get this started. I’m like, just give me six months. But most of the time at the end, they realize this is a lifestyle. Like this is a decision I’m gonna make every day because it serves me, because this is what keeps me healthy. And so I’m wondering if you have any thoughts for people who are struggling to maintain a healthy lifestyle?
Sure. So I would say that it can just be so overwhelming. I mean, like for all of us with all the things that we’re up against in that I would really try and focus on again, when I said inflammation and people get deer in the headlights. Just start with diets, start with trying to switch out things and really your body gets accustomed to it. It really does get accustomed to good food. And then when you put in bad food, your body’s like, this is not working for me. And you know, it’s kind of like, I understand that this is it’s never over. It’s never something that I’m like you said, it’s not, oh, I’m one and done. But I really do, I try and do my best. I just try and plan ahead. Plan ahead.
Surround yourself with people who are encouraging to you. Detox from people who are not on the same path as you. Sometimes you have to give up relationships with people who liked to have cocktails and things, just to get yourself back on track. So really surround yourself with people that understand that. And will be on that path with you. Team up with practitioners who understand you, who would listen to you. Who are not just gonna give up and give the diagnosis and it’s over. Educate yourself, listen to this entire pod, like listen to this entire summit. I am gonna be sitting here listen to this entire summit. It’s gonna be just amazing. And then stay with this community. Keep educating, keep going. If you have a day where you messed up, just wake up the next day and just doing your best. We are our best when we take care of ourselves. So I know self care for a lot of people is like, I can’t do it, I don’t have time whenever. Every ounce we put into ourselves, we get a huge ROI for the people around us too.
I think that’s so important for caregivers to hear. Our Alzheimer’s patients are one thing. And of course, we’re speaking to them in this summit and yet so many of our attendees and listeners going to be the caregivers. And one of the shocking statistics is how much more frequently caregivers for someone of Alzheimer’s end up with Alzheimer’s themselves.
Not necessarily because of the genetics, but because the lifestyle associated with caregiving puts you at higher risk, the stress, the isolation, all of it can make you at much higher risk for developing dementia yourself. And so hearing that it’s like you’ve got to put your oxygen mask on first before you help someone else. I know as demanding as caregiving can be it can feel like a lot, but you’ve got to help yourself. You’ve got to put that self care first. Make sure you’re eating a really healthy diet. You’re giving in your 10,000 steps and exercising regularly. You’re getting good sleep. And if you’re not prioritizing getting some hope.
Dr. Kelly, it’s been such a pleasure to have you here. Do you have any parting thoughts? And then absolutely I need you to share where people can learn more about your practice and all that you have to offer.
Yeah, I think I’m full of all kinds of thoughts and I literally am always publishing some kind of article and things. So I will let the viewers choose their own, what do they wanna read from parting thoughts, so just go to drkellyhalderman.com. I put lots of articles there. I put buttons that say print and bring to your physician. Like with all kinds of information that is published and things, because I want people to be their own advocate. I want them to know that they have a say in their care and things. So follow me there. I’m on every Instagram, Twitter, you know, everywhere. I’m the only Kelly Halderman in town. It’s usually me. So I’m just really thankful to you, Dr. Heather. This is such an important topic. I’m so grateful that you have me on, and I’m so grateful to listen to the rest of the interview. So thank you.
I learned so much, thank you so much for being here. I felt so privileged to have to be hosting this summit because they get to talk to incredible doctors like you. And I learned a bunch just from our conversation and you have phenomenal resources that I just learned about. That I’m gonna go check out because there are, it can this be so daunting, it can feel so overwhelming. And just having that cheat sheet when you go in to talk to a doctor which can be intimidating, especially that first visit to go in with some resources that help guide that so that you get the most out of the care, the most out of your time with them is just so valuable I can’t thank you enough.
I’m sure that took a bunch of time to put together and lots of thoughts, lots of expertise on your end. So thank you for publishing that and making it available. And I encourage all of you who are listening, go to her website, download those, put them in the folder that you take to your next doctor’s visit, ’cause that is gonna be super helpful. Thank you again for spending your time with us and for sharing all of your wisdom and expertise.
You’re welcome, thank you so much.
Wow, I just had one of the best conversations ever with Dr. Kelly Halderman. She makes detox fun. She makes it exciting. And she does a great job of explaining why it’s so essential to reversing Alzheimer’s. She breaks it down and makes it easy to make simple shifts in our habits that are huge when it comes to reducing inflammation, reducing toxins and reducing your risk for Alzheimer’s disease. She is incredible. Be sure to listen all the way to the end to get the most valuable tips about how to talk to your doctor, and what you can do to make sure that you can stick to a plan that only to get you healthy, but to keep you healthy. She’s an inspiration, she reversed her own MS. So she speaks not only as a super smart medical doctor, but also as a patient and even a parent. She’s incredible. I hope you enjoyed this conversation as much as I did.
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